Markers / Gene
ARMS2
One position in this gene is readable from a home DNA test.
Age-related macular degeneration, second locus
rs10490924 · chr10:124,214,448 · G/T · evidence: established
The other major common-variant contributor to macular degeneration, independent of CFH. Carrying risk versions of both raises risk considerably more than either alone.
| If you carry | What it means |
|---|---|
| No copies | You have the lower-risk version on both copies |
| One copy | One higher-risk copy, roughly 2 to 3 times the background risk |
| Two copies | Two higher-risk copies, roughly 6 to 8 times the background risk |
| Ancestry group | T (the effect version) | |
|---|---|---|
| African | 24.6% | |
| American | 24.8% | |
| East Asian | 40.4% | |
| European | 19.5% | |
| South Asian | 34.3% |
1000 Genomes Project phase 3, via Ensembl, retrieved 2026-09-23. These groupings are coarse and flatten a great deal of internal diversity, particularly within Africa. A variant being common somewhere tells you where a piece of your ancestry probably comes from, and nothing else.
Where this gene fits
If you have taken a home DNA test, these positions are already in your file.
Read my file