Markers / Gene
CFH
One position in this gene is readable from a home DNA test.
Age-related macular degeneration, CFH
rs1061170 · chr1:196,659,237 · T/C · evidence: established
The leading cause of sight loss in older adults in wealthy countries. This change in complement factor H was the first common variant found for it and has one of the largest effect sizes of any common disease variant known.
| If you carry | What it means |
|---|---|
| No copies | You have the lower-risk version on both copies |
| One copy | One higher-risk copy, roughly 2 to 3 times the background risk |
| Two copies | Two higher-risk copies, roughly 5 to 7 times the background risk |
| Ancestry group | C (the effect version) | |
|---|---|---|
| African | 36.2% | |
| American | 23.3% | |
| East Asian | 4.9% | |
| European | 36.2% | |
| South Asian | 28.7% |
1000 Genomes Project phase 3, via Ensembl, retrieved 2026-09-23. These groupings are coarse and flatten a great deal of internal diversity, particularly within Africa. A variant being common somewhere tells you where a piece of your ancestry probably comes from, and nothing else.
Where this gene fits
If you have taken a home DNA test, these positions are already in your file.
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