Markers / Gene
FOXO3
One position in this gene is readable from a home DNA test.
FOXO3, one of the few replicated longevity variants
rs2802292 · chr6:108,908,518 · G/T · evidence: moderate
Very few genetic variants have been linked to human lifespan and survived replication. FOXO3 is one of the two that have, alongside APOE, and it has been found in Japanese, German, Italian, American and Chinese cohorts independently.
| If you carry | What it means |
|---|---|
| No copies | You do not carry the longevity-associated version |
| One copy | One copy, a slight nudge towards reaching very old age |
| Two copies | Two copies, the strongest form of a genuinely small effect |
| Ancestry group | G (the effect version) | |
|---|---|---|
| African | 82.9% | |
| American | 39.0% | |
| East Asian | 30.6% | |
| European | 43.3% | |
| South Asian | 56.1% |
1000 Genomes Project phase 3, via Ensembl, retrieved 2026-09-23. These groupings are coarse and flatten a great deal of internal diversity, particularly within Africa. A variant being common somewhere tells you where a piece of your ancestry probably comes from, and nothing else.
If you have taken a home DNA test, these positions are already in your file.
Read my file