Markers / Gene
HLA-DQA1
One position in this gene is readable from a home DNA test.
Coeliac disease risk type
rs2187668 · chr6:32,605,884 · C/T · evidence: strong
Coeliac disease requires a specific immune receptor type to be possible at all. This position tags the main one, HLA-DQ2.5. Its real value is the negative: without a permitting type, coeliac disease is very nearly ruled out.
| If you carry | What it means |
|---|---|
| No copies | DQ2.5 not detected |
| One copy | DQ2.5 present, one copy |
| Two copies | DQ2.5 present, two copies |
| Ancestry group | T (the effect version) | |
|---|---|---|
| African | 5.4% | |
| American | 11.8% | |
| East Asian | 5.2% | |
| European | 10.6% | |
| South Asian | 7.9% |
1000 Genomes Project phase 3, via Ensembl, retrieved 2026-09-23. These groupings are coarse and flatten a great deal of internal diversity, particularly within Africa. A variant being common somewhere tells you where a piece of your ancestry probably comes from, and nothing else.
Where this gene fits
If you have taken a home DNA test, these positions are already in your file.
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