Markers / Gene
LZTFL1 region
2 positions in this gene are readable from a home DNA test.
Neanderthal: the chromosome 3 COVID risk haplotype
rs35044562 · chr3:45,909,024 · A/G · evidence: established
A 50,000-letter stretch of chromosome 3, inherited whole from Neanderthals, turned out to be the single strongest genetic risk factor for severe COVID-19. It is carried by roughly half of people in South Asia, around one in six Europeans, and almost nobody in East Asia.
| If you carry | What it means |
|---|---|
| No copies | You did not inherit this Neanderthal stretch |
| One copy | You inherited it from one parent |
| Two copies | You inherited it from both parents |
| Ancestry group | G (the effect version) | |
|---|---|---|
| African | 0.4% | |
| American | 4.5% | |
| East Asian | 0.5% | |
| European | 8.0% | |
| South Asian | 29.6% |
1000 Genomes Project phase 3, via Ensembl, retrieved 2026-09-23. These groupings are coarse and flatten a great deal of internal diversity, particularly within Africa. A variant being common somewhere tells you where a piece of your ancestry probably comes from, and nothing else.
Neanderthal: chromosome 3 haplotype, second marker
rs10490770 · chr3:45,864,732 · T/C · evidence: established
A second position inside the same inherited Neanderthal stretch, included because chips differ in which of the two they carry.
| If you carry | What it means |
|---|---|
| No copies | Not inherited |
| One copy | Inherited from one parent |
| Two copies | Inherited from both parents |
| Ancestry group | C (the effect version) | |
|---|---|---|
| African | 0.4% | |
| American | 4.3% | |
| East Asian | 0.5% | |
| European | 8.1% | |
| South Asian | 29.6% |
1000 Genomes Project phase 3, via Ensembl, retrieved 2026-09-23. These groupings are coarse and flatten a great deal of internal diversity, particularly within Africa. A variant being common somewhere tells you where a piece of your ancestry probably comes from, and nothing else.
Where this gene fits
If you have taken a home DNA test, these positions are already in your file.
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