Markers / Gene
OPRM1
One position in this gene is readable from a home DNA test.
Opioid receptor variant A118G
rs1799971 · chr6:154,360,797 · A/G · evidence: moderate
This changes the main receptor that opioid painkillers act on. It has been studied for morphine dose requirements after surgery and for response to naltrexone in treating alcohol dependence.
| If you carry | What it means |
|---|---|
| No copies | You have the common version of the receptor |
| One copy | One copy of the variant receptor |
| Two copies | Two copies of the variant receptor |
| Ancestry group | G (the effect version) | |
|---|---|---|
| African | 0.9% | |
| American | 20.0% | |
| East Asian | 39.3% | |
| European | 16.2% | |
| South Asian | 41.8% |
1000 Genomes Project phase 3, via Ensembl, retrieved 2026-09-23. These groupings are coarse and flatten a great deal of internal diversity, particularly within Africa. A variant being common somewhere tells you where a piece of your ancestry probably comes from, and nothing else.
Where this gene fits
If you have taken a home DNA test, these positions are already in your file.
Read my file