Markers / Gene
TLR1
One position in this gene is readable from a home DNA test.
How loudly your innate immune system shouts
rs4833095 · chr4:38,799,710 · T/C · evidence: strong
Toll-like receptors are the immune system's first alarm, recognising bacteria within minutes. This variant lowers the response. It shows one of the strongest signals of recent selection in Europeans, and the likely trade is a quieter alarm in exchange for less collateral inflammation.
| If you carry | What it means |
|---|---|
| No copies | You have the stronger-responding version on both copies |
| One copy | You carry one lower-responding copy |
| Two copies | You have the lower-responding version on both copies |
| Ancestry group | C (the effect version) | |
|---|---|---|
| African | 88.0% | |
| American | 47.3% | |
| East Asian | 59.9% | |
| European | 28.0% | |
| South Asian | 51.2% |
1000 Genomes Project phase 3, via Ensembl, retrieved 2026-09-23. These groupings are coarse and flatten a great deal of internal diversity, particularly within Africa. A variant being common somewhere tells you where a piece of your ancestry probably comes from, and nothing else.
If you have taken a home DNA test, these positions are already in your file.
Read my file