Markers / Gene
TNF
One position in this gene is readable from a home DNA test.
Tumour necrosis factor, the inflammation dial
rs1800629 · chr6:31,543,031 · G/A · evidence: moderate
TNF is one of the body's strongest inflammatory signals, and blocking it is the basis of several major drugs for rheumatoid arthritis and inflammatory bowel disease. This promoter variant is associated with producing more of it.
| If you carry | What it means |
|---|---|
| No copies | You have the lower-output version on both copies |
| One copy | You carry one higher-output copy |
| Two copies | You carry two higher-output copies |
| Ancestry group | A (the effect version) | |
|---|---|---|
| African | 12.0% | |
| American | 6.9% | |
| East Asian | 5.9% | |
| European | 13.4% | |
| South Asian | 5.3% |
1000 Genomes Project phase 3, via Ensembl, retrieved 2026-09-23. These groupings are coarse and flatten a great deal of internal diversity, particularly within Africa. A variant being common somewhere tells you where a piece of your ancestry probably comes from, and nothing else.
Where this gene fits
If you have taken a home DNA test, these positions are already in your file.
Read my file