rs2282679
Vitamin D binding protein
What this position does
GC makes the protein that carries vitamin D around the body. This is the strongest common genetic influence on measured vitamin D levels, and it works by changing how much circulating vitamin D is bound.
What each result means
| If you carry | What it means |
|---|---|
| No copies of the effect version TT | You do not carry the lower-level version Neither copy carries the lower-level version. |
| One copy GT | One copy, so modestly lower vitamin D on a blood test Associated on average with modestly lower measured vitamin D. |
| Two copies GG | Two copies, so the lowest average vitamin D on a blood test Associated with the lowest average measured vitamin D, and with a higher chance of being classified deficient on a blood test. |
Worth knowing. Latitude, season, skin tone and how much time you spend outside all matter more than this. A blood test settles it for about the price of a takeaway.
How common each version is
| Ancestry group | G (the effect version) | |
|---|---|---|
| African | 5.0% | |
| American | 20.9% | |
| East Asian | 26.1% | |
| European | 24.7% | |
| South Asian | 29.7% |
1000 Genomes Project phase 3, via Ensembl, retrieved 2026-09-23. These groupings are coarse and flatten a great deal of internal diversity, particularly within Africa. A variant being common somewhere tells you where a piece of your ancestry probably comes from, and nothing else.
How many people carry each result
| Ancestry group | TT | GT | GG |
|---|---|---|---|
| African | 596 / 661 | 64 / 661 | 1 / 661 |
| European | 282 / 503 | 194 / 503 | 27 / 503 |
| East Asian | 275 / 504 | 195 / 504 | 34 / 504 |
| South Asian | 244 / 489 | 200 / 489 | 45 / 489 |
| American | 213 / 347 | 123 / 347 | 11 / 347 |
Counts of people, not modelled frequencies: every one of the 2,504 individuals sequenced by the 1000 Genomes Project phase 3, tallied by the genotype they carry. Deriving these from allele frequencies instead would assume random mating inside each group and undercount the homozygotes.
How to find out which you have
If you have taken a test with 23andMe, AncestryDNA, MyHeritage, Family Tree DNA, TellMeGen or Living DNA, this position is very likely already in the raw data file they gave you. You do not need another test.
One thing to watch if you look it up by hand: testing companies report some positions from one DNA strand and some from the other, and the file does not say which. Read the letters as they appear and you will get the opposite of the truth for some positions. Sequencings resolves that automatically.
Source
Coordinates and allele pair verified against Ensembl GRCh37. Direction of effect verified against VEP protein consequences or 1000 Genomes population frequency. Category: Health-adjacent.
Related
- rs7041 — The vitamin D carrier protein, second marker
Where this fits
Common questions
What is rs2282679?
rs2282679 is a position in the GC gene on chromosome 4. GC makes the protein that carries vitamin D around the body. This is the strongest common genetic influence on measured vitamin D levels, and it works by changing how much circulating vitamin D is bound.
What does it mean if I have GG at rs2282679?
Two copies, so the lowest average vitamin D on a blood test. Associated with the lowest average measured vitamin D, and with a higher chance of being classified deficient on a blood test.
What does it mean if I have TT at rs2282679?
You do not carry the lower-level version. Neither copy carries the lower-level version.
How do I find out my rs2282679 genotype?
If you have taken a home DNA test, this position is very likely in the raw data file you were given. Sequencings reads that file in your browser without uploading it, and resolves which DNA strand each position was reported from, which is the step most manual lookups get wrong.
This is reference information, not medical advice, and not a diagnosis. See the medical disclaimer. Category: Health-adjacent.