Markers / between CYP1A1 and CYP1A2
rs2472297
How much coffee you actually drink
What this position does
This is not about whether caffeine affects you. It is about how much coffee people with this version end up drinking, which turns out to be one of the most reliably replicated findings in the whole of behavioural genetics. People who clear caffeine faster drink more of it to get the same effect.
What each result means
| If you carry | What it means |
|---|---|
| No copies of the effect version CC | Typically lower coffee intake Neither copy carries the higher-intake version. |
| One copy CT | Typically higher coffee intake One copy. Associated on average with drinking meaningfully more coffee per day. |
| Two copies TT | Typically highest coffee intake Two copies, the strongest association with higher daily coffee consumption. |
Worth knowing. An average across many thousands of people. Plenty of people with the high-intake version drink tea.
How common each version is
| Ancestry group | T (the effect version) | |
|---|---|---|
| African | 1.4% | |
| American | 8.9% | |
| East Asian | 0.0% | |
| European | 21.5% | |
| South Asian | 3.3% |
1000 Genomes Project phase 3, via Ensembl, retrieved 2026-09-23. These groupings are coarse and flatten a great deal of internal diversity, particularly within Africa. A variant being common somewhere tells you where a piece of your ancestry probably comes from, and nothing else.
How many people carry each result
| Ancestry group | CC | CT | TT |
|---|---|---|---|
| African | 642 / 661 | 19 / 661 | 0 / 661 |
| European | 312 / 503 | 166 / 503 | 25 / 503 |
| East Asian | 504 / 504 | 0 / 504 | 0 / 504 |
| South Asian | 457 / 489 | 32 / 489 | 0 / 489 |
| American | 288 / 347 | 56 / 347 | 3 / 347 |
Counts of people, not modelled frequencies: every one of the 2,504 individuals sequenced by the 1000 Genomes Project phase 3, tallied by the genotype they carry. Deriving these from allele frequencies instead would assume random mating inside each group and undercount the homozygotes.
How to find out which you have
If you have taken a test with 23andMe, AncestryDNA, MyHeritage, Family Tree DNA, TellMeGen or Living DNA, this position is very likely already in the raw data file they gave you. You do not need another test.
One thing to watch if you look it up by hand: testing companies report some positions from one DNA strand and some from the other, and the file does not say which. Read the letters as they appear and you will get the opposite of the truth for some positions. Sequencings resolves that automatically.
Source
Coordinates and allele pair verified against Ensembl GRCh37. Direction of effect verified against VEP protein consequences or 1000 Genomes population frequency. Category: Trait.
Where this fits
Common questions
What is rs2472297?
rs2472297 is a position in the between CYP1A1 and CYP1A2 gene on chromosome 15. This is not about whether caffeine affects you. It is about how much coffee people with this version end up drinking, which turns out to be one of the most reliably replicated findings in the whole of behavioural genetics. People who clear caffeine faster drink more of it to get the same effect.
What does it mean if I have TT at rs2472297?
Typically highest coffee intake. Two copies, the strongest association with higher daily coffee consumption.
What does it mean if I have CC at rs2472297?
Typically lower coffee intake. Neither copy carries the higher-intake version.
How do I find out my rs2472297 genotype?
If you have taken a home DNA test, this position is very likely in the raw data file you were given. Sequencings reads that file in your browser without uploading it, and resolves which DNA strand each position was reported from, which is the step most manual lookups get wrong.
This is reference information, not medical advice, and not a diagnosis. See the medical disclaimer. Category: Trait.