rs4369876
Neanderthal: pain sensitivity, V991L
What this position does
The second of the three Neanderthal changes in the pain-signalling sodium channel.
What each result means
| If you carry | What it means |
|---|---|
| No copies of the effect version CC | Not inherited Neither copy carries this Neanderthal change. |
| One copy AC | Inherited from one parent One copy. The three variants act together, so the effect depends on how many of them you carry. |
| Two copies AA | Inherited from both parents Two copies. |
How common each version is
| Ancestry group | A (the effect version) | |
|---|---|---|
| African | 0.3% | |
| American | 12.7% | |
| East Asian | 6.1% | |
| European | 0.0% | |
| South Asian | 1.3% |
1000 Genomes Project phase 3, via Ensembl, retrieved 2026-09-23. These groupings are coarse and flatten a great deal of internal diversity, particularly within Africa. A variant being common somewhere tells you where a piece of your ancestry probably comes from, and nothing else.
How many people carry each result
| Ancestry group | CC | AC | AA |
|---|---|---|---|
| African | 657 / 661 | 4 / 661 | 0 / 661 |
| European | 503 / 503 | 0 / 503 | 0 / 503 |
| East Asian | 445 / 504 | 57 / 504 | 2 / 504 |
| South Asian | 476 / 489 | 13 / 489 | 0 / 489 |
| American | 266 / 347 | 74 / 347 | 7 / 347 |
Counts of people, not modelled frequencies: every one of the 2,504 individuals sequenced by the 1000 Genomes Project phase 3, tallied by the genotype they carry. Deriving these from allele frequencies instead would assume random mating inside each group and undercount the homozygotes.
How to find out which you have
If you have taken a test with 23andMe, AncestryDNA, MyHeritage, Family Tree DNA, TellMeGen or Living DNA, this position is very likely already in the raw data file they gave you. You do not need another test.
One thing to watch if you look it up by hand: testing companies report some positions from one DNA strand and some from the other, and the file does not say which. Read the letters as they appear and you will get the opposite of the truth for some positions. Sequencings resolves that automatically.
Source
Coordinates and allele pair verified against Ensembl GRCh37. Direction of effect verified against VEP protein consequences or 1000 Genomes population frequency. Category: Archaic DNA.
Related
- rs3750904 — Neanderthal: pain sensitivity, D1908G
- rs12478318 — Neanderthal: pain sensitivity, M932L
Where this fits
Common questions
What is rs4369876?
rs4369876 is a position in the SCN9A gene on chromosome 2. The second of the three Neanderthal changes in the pain-signalling sodium channel.
What does it mean if I have AA at rs4369876?
Inherited from both parents. Two copies.
What does it mean if I have CC at rs4369876?
Not inherited. Neither copy carries this Neanderthal change.
How do I find out my rs4369876 genotype?
If you have taken a home DNA test, this position is very likely in the raw data file you were given. Sequencings reads that file in your browser without uploading it, and resolves which DNA strand each position was reported from, which is the step most manual lookups get wrong.
This is reference information, not medical advice, and not a diagnosis. See the medical disclaimer. Category: Archaic DNA.