rs1726866
Tasting bitterness in brassicas
What this position does
TAS2R38 detects a specific bitter compound found in broccoli, sprouts and kale. Two common versions of the receptor differ at three positions, and one of them barely works.
What each result means
| If you carry | What it means |
|---|---|
| No copies of the effect version AA | Likely a non-taster at this position Two copies of the version found in the poorly-working receptor. |
| One copy AG | Intermediate One of each. Most people sit here and taste the compound moderately. |
| Two copies GG | Likely a taster at this position Two copies of the version found in the working receptor, which makes those vegetables taste strongly bitter. |
Worth knowing. The receptor is defined by three positions together. The third has two alleles that are mirror images of each other, so no consumer file can be oriented reliably there, and this report uses the two that can be. That makes it a good estimate of your haplotype rather than a reading of it.
How common each version is
How many people carry each result
How to find out which you have
If you have taken a test with 23andMe, AncestryDNA, MyHeritage, Family Tree DNA, TellMeGen or Living DNA, this position is very likely already in the raw data file they gave you. You do not need another test.
One thing to watch if you look it up by hand: testing companies report some positions from one DNA strand and some from the other, and the file does not say which. Read the letters as they appear and you will get the opposite of the truth for some positions. Sequencings resolves that automatically.
Source
Coordinates and allele pair verified against Ensembl GRCh37. Direction of effect verified against VEP protein consequences or 1000 Genomes population frequency. Category: Trait.
Related
- rs10246939 — Bitter receptor, second position
Where this fits
Common questions
What is rs1726866?
rs1726866 is a position in the TAS2R38 gene on chromosome 7. TAS2R38 detects a specific bitter compound found in broccoli, sprouts and kale. Two common versions of the receptor differ at three positions, and one of them barely works.
What does it mean if I have GG at rs1726866?
Likely a taster at this position. Two copies of the version found in the working receptor, which makes those vegetables taste strongly bitter.
What does it mean if I have AA at rs1726866?
Likely a non-taster at this position. Two copies of the version found in the poorly-working receptor.
How do I find out my rs1726866 genotype?
If you have taken a home DNA test, this position is very likely in the raw data file you were given. Sequencings reads that file in your browser without uploading it, and resolves which DNA strand each position was reported from, which is the step most manual lookups get wrong.
This is reference information, not medical advice, and not a diagnosis. See the medical disclaimer. Category: Trait.