rs2231142
ABCG2, statin response and uric acid
What this position does
ABCG2 is a transporter that pumps drugs and waste out of cells. This reduced-function change raises blood levels of rosuvastatin and is also one of the strongest common genetic causes of raised uric acid and gout.
What each result means
| If you carry | What it means |
|---|---|
| No copies of the effect version GG | You have normal transporter function Normal transporter function. |
| One copy GT | Decreased function Higher rosuvastatin blood levels at a given dose, and a raised risk of gout. Guidelines suggest capping rosuvastatin dose for this genotype. |
| Two copies TT | Poor function Markedly higher rosuvastatin exposure and a substantially raised gout risk. Both are worth mentioning to a doctor. |
How common each version is
| Ancestry group | T (the effect version) | |
|---|---|---|
| African | 1.3% | |
| American | 14.1% | |
| East Asian | 29.1% | |
| European | 9.4% | |
| South Asian | 9.7% |
1000 Genomes Project phase 3, via Ensembl, retrieved 2026-09-23. These groupings are coarse and flatten a great deal of internal diversity, particularly within Africa. A variant being common somewhere tells you where a piece of your ancestry probably comes from, and nothing else.
How many people carry each result
| Ancestry group | GG | GT | TT |
|---|---|---|---|
| African | 644 / 661 | 17 / 661 | 0 / 661 |
| European | 414 / 503 | 83 / 503 | 6 / 503 |
| East Asian | 251 / 504 | 213 / 504 | 40 / 504 |
| South Asian | 396 / 489 | 91 / 489 | 2 / 489 |
| American | 255 / 347 | 86 / 347 | 6 / 347 |
Counts of people, not modelled frequencies: every one of the 2,504 individuals sequenced by the 1000 Genomes Project phase 3, tallied by the genotype they carry. Deriving these from allele frequencies instead would assume random mating inside each group and undercount the homozygotes.
How to find out which you have
If you have taken a test with 23andMe, AncestryDNA, MyHeritage, Family Tree DNA, TellMeGen or Living DNA, this position is very likely already in the raw data file they gave you. You do not need another test.
One thing to watch if you look it up by hand: testing companies report some positions from one DNA strand and some from the other, and the file does not say which. Read the letters as they appear and you will get the opposite of the truth for some positions. Sequencings resolves that automatically.
Source
CPIC Guideline for Statins and SLCO1B1, ABCG2 and CYP2C9
Coordinates and allele pair verified against Ensembl GRCh37. Direction of effect verified against VEP protein consequences or 1000 Genomes population frequency. Category: Medicine response.
Where this fits
Common questions
What is rs2231142?
rs2231142 is a position in the ABCG2 gene on chromosome 4. ABCG2 is a transporter that pumps drugs and waste out of cells. This reduced-function change raises blood levels of rosuvastatin and is also one of the strongest common genetic causes of raised uric acid and gout.
What does it mean if I have TT at rs2231142?
Poor function. Markedly higher rosuvastatin exposure and a substantially raised gout risk. Both are worth mentioning to a doctor.
What does it mean if I have GG at rs2231142?
You have normal transporter function. Normal transporter function.
How do I find out my rs2231142 genotype?
If you have taken a home DNA test, this position is very likely in the raw data file you were given. Sequencings reads that file in your browser without uploading it, and resolves which DNA strand each position was reported from, which is the step most manual lookups get wrong.
This is reference information, not medical advice, and not a diagnosis. See the medical disclaimer. Category: Medicine response.