Markers / Gene
CYP2D6
2 positions in this gene are readable from a home DNA test.
CYP2D6 *4, the most common non-working version
rs3892097 · chr22:42,524,947 · C/T · evidence: established
CYP2D6 handles roughly a quarter of all prescribed drugs, including codeine, tramadol, tamoxifen and many antidepressants. The *4 version does not work at all and is the most common cause of poor metabolism in European populations.
| If you carry | What it means |
|---|---|
| No copies | No *4 copy |
| One copy | One *4 copy |
| Two copies | Two *4 copies |
CYP2D6 *10, reduced function
rs1065852 · chr22:42,526,694 · G/A · evidence: established
A reduced-function CYP2D6 version that is uncommon in Europe and carried by roughly half of people of East Asian descent, where it is the main cause of reduced CYP2D6 activity.
| If you carry | What it means |
|---|---|
| No copies | You do not carry *10 |
| One copy | One reduced-function copy |
| Two copies | Two reduced-function copies |
Where this gene fits
If you have taken a home DNA test, these positions are already in your file.
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