rs1065852
CYP2D6 *10, reduced function
What this position does
A reduced-function CYP2D6 version that is uncommon in Europe and carried by roughly half of people of East Asian descent, where it is the main cause of reduced CYP2D6 activity.
What each result means
| If you carry | What it means |
|---|---|
| No copies of the effect version GG | You do not carry *10 Normal function at this position. |
| One copy AG | One reduced-function copy Reduced activity from this copy. |
| Two copies AA | Two reduced-function copies Substantially reduced CYP2D6 activity. The same drugs are affected as for *4, generally less severely. |
Worth knowing. The same copy-number blind spot applies as for *4.
How common each version is
How many people carry each result
How to find out which you have
If you have taken a test with 23andMe, AncestryDNA, MyHeritage, Family Tree DNA, TellMeGen or Living DNA, this position is very likely already in the raw data file they gave you. You do not need another test.
One thing to watch if you look it up by hand: testing companies report some positions from one DNA strand and some from the other, and the file does not say which. Read the letters as they appear and you will get the opposite of the truth for some positions. Sequencings resolves that automatically.
Source
CPIC Guideline for Codeine and CYP2D6
Coordinates and allele pair verified against Ensembl GRCh37. Direction of effect verified against VEP protein consequences or 1000 Genomes population frequency. Category: Medicine response.
Related
- rs3892097 — CYP2D6 *4, the most common non-working version
Where this fits
Common questions
What is rs1065852?
rs1065852 is a position in the CYP2D6 gene on chromosome 22. A reduced-function CYP2D6 version that is uncommon in Europe and carried by roughly half of people of East Asian descent, where it is the main cause of reduced CYP2D6 activity.
What does it mean if I have AA at rs1065852?
Two reduced-function copies. Substantially reduced CYP2D6 activity. The same drugs are affected as for *4, generally less severely.
What does it mean if I have GG at rs1065852?
You do not carry *10. Normal function at this position.
How do I find out my rs1065852 genotype?
If you have taken a home DNA test, this position is very likely in the raw data file you were given. Sequencings reads that file in your browser without uploading it, and resolves which DNA strand each position was reported from, which is the step most manual lookups get wrong.
This is reference information, not medical advice, and not a diagnosis. See the medical disclaimer. Category: Medicine response.