rs3892097
CYP2D6 *4, the most common non-working version
What this position does
CYP2D6 handles roughly a quarter of all prescribed drugs, including codeine, tramadol, tamoxifen and many antidepressants. The *4 version does not work at all and is the most common cause of poor metabolism in European populations.
What each result means
| If you carry | What it means |
|---|---|
| No copies of the effect version CC | No *4 copy Normal function at this position. |
| One copy CT | One *4 copy One non-working copy. Combined with a normal second copy this usually means intermediate metabolism. |
| Two copies TT | Two *4 copies Poor metaboliser. Codeine and tramadol are inactive prodrugs that CYP2D6 converts into the active painkiller, so they may do very little for you. Several antidepressants are cleared by the same enzyme and can build up. Worth mentioning to a prescriber. |
Worth knowing. CYP2D6 is the hardest gene in pharmacogenomics to read properly. Whole copies of it are deleted or duplicated between people, and a genotyping chip cannot see copy number at all. Two normal-looking copies can hide three working ones. This is a partial read, not a star-allele result.
How common each version is
How many people carry each result
How to find out which you have
If you have taken a test with 23andMe, AncestryDNA, MyHeritage, Family Tree DNA, TellMeGen or Living DNA, this position is very likely already in the raw data file they gave you. You do not need another test.
One thing to watch if you look it up by hand: testing companies report some positions from one DNA strand and some from the other, and the file does not say which. Read the letters as they appear and you will get the opposite of the truth for some positions. Sequencings resolves that automatically.
Source
CPIC Guideline for Codeine and CYP2D6
Coordinates and allele pair verified against Ensembl GRCh37. Direction of effect verified against VEP protein consequences or 1000 Genomes population frequency. Category: Medicine response.
Related
- rs1065852 — CYP2D6 *10, reduced function
Where this fits
Common questions
What is rs3892097?
rs3892097 is a position in the CYP2D6 gene on chromosome 22. CYP2D6 handles roughly a quarter of all prescribed drugs, including codeine, tramadol, tamoxifen and many antidepressants. The *4 version does not work at all and is the most common cause of poor metabolism in European populations.
What does it mean if I have TT at rs3892097?
Two *4 copies. Poor metaboliser. Codeine and tramadol are inactive prodrugs that CYP2D6 converts into the active painkiller, so they may do very little for you. Several antidepressants are cleared by the same enzyme and can build up. Worth mentioning to a prescriber.
What does it mean if I have CC at rs3892097?
No *4 copy. Normal function at this position.
How do I find out my rs3892097 genotype?
If you have taken a home DNA test, this position is very likely in the raw data file you were given. Sequencings reads that file in your browser without uploading it, and resolves which DNA strand each position was reported from, which is the step most manual lookups get wrong.
This is reference information, not medical advice, and not a diagnosis. See the medical disclaimer. Category: Medicine response.